Adipogenesis of murine embryonic stem cells in a three-dimensional culture system using electrospun polymer scaffolds
X Kang, Y Xie, HM Powell, LJ Lee, MA Belury… - Biomaterials, 2007 - Elsevier
A mechanistic understanding of adipose tissue differentiation is critical for the treatment and
prevention of obesity and type 2 diabetes. Conventional in vitro models of adipogenesis are
preadipocytes or freshly isolated adipocytes grown in two-dimensional (2D) cultures.
Optimal results using in vitro tissue culture models can be expected only when adipocyte
models closely resemble adipose tissue in vivo. Thus the design of an in vitro three-
dimensional (3D) model which faithfully mimics the in vivo environment is needed to …
prevention of obesity and type 2 diabetes. Conventional in vitro models of adipogenesis are
preadipocytes or freshly isolated adipocytes grown in two-dimensional (2D) cultures.
Optimal results using in vitro tissue culture models can be expected only when adipocyte
models closely resemble adipose tissue in vivo. Thus the design of an in vitro three-
dimensional (3D) model which faithfully mimics the in vivo environment is needed to …
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