An experimentally based, quantitative understanding of the entrapment and function of small
peptides within PEO brush layers does not currently exist. Earlier work provided a rationale
for expecting that an ordered, compact peptide will enter the PEO phase more readily than a
peptide of similar size that adopts a less ordered, less compact form, and that amphiphilicity
will promote peptide retention within the hydrophobic region of the PEO brush. Here we
more deliberately describe criteria for peptide integration and structural change within the …