Circulating osteoprogenitor (COP) cells are blood-borne cells which express a variety of
osteoblastic markers and are able to form bone nodules in vivo. Whereas a high percentage
of COP cells (% COP) is associated with vascular calcification, low% COP has been
associated with disability and frailty. However, the reference range of% COP in age-and
gender-matching populations, and the age-related changes in% COP remain unknown. A
cross-sectional study was undertaken in 144 healthy volunteers in Western Sydney (20–90 …