Aldose reductase inhibitors from the leaves of Myrciaria dubia (HB & K.) McVaugh
H Ueda, E Kuroiwa, Y Tachibana, K Kawanishi, F Ayala… - Phytomedicine, 2004 - Elsevier
Ellagic acid (1) and its two derivatives, 4-O-methylellagic acid (2) and 4-(α-
rhamnopyranosyl) ellagic acid (3) were isolated as inhibitors of aldose reductase (AR) from
Myrciaria dubia (HB & K.) McVaugh. Compound 2 was the first isolated from the nature.
Compound 3 showed the strongest inhibition against human recombinant AR (HRAR) and
rat lens AR (RLAR). Inhibitory activity of compound 3 against HRAR (IC50 value= 4.1× 10−
8M) was 60 times more than that of quercetin (2.5× 10− 6M). The type of inhibition against …
rhamnopyranosyl) ellagic acid (3) were isolated as inhibitors of aldose reductase (AR) from
Myrciaria dubia (HB & K.) McVaugh. Compound 2 was the first isolated from the nature.
Compound 3 showed the strongest inhibition against human recombinant AR (HRAR) and
rat lens AR (RLAR). Inhibitory activity of compound 3 against HRAR (IC50 value= 4.1× 10−
8M) was 60 times more than that of quercetin (2.5× 10− 6M). The type of inhibition against …
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