Rationale: There is a need for improved therapeutic interventions to treat both drug-and
sleep-induced respiratory depression. Increased understanding of the neurochemical
control of respiration will help identify a basis for advances. Activation of α-amino-3-hydroxy-
5-methyl-4-isoxazolepropionic acid (AMPA)–type glutamate receptors positively modulates
respiratory drive and rhythmogenesis in several brain regions including the pre-Bötzinger
complex. Ampakines are a diverse group of small molecules that activate subsets of these …

Rationale: There is a need for improved therapeutic interventions to treat both drug‐and
sleep‐induced respiratory depression. Activation of AMPA‐type glutamate receptors
positively modulates respiratory drive and rhythmogenesis in several brain regions including
the preBötzinger complex. Ampakines are a diverse group of small molecules that activate
subsets of these receptors. Objective: We determined whether the ampakine CX546 would
enhance respiratory drive and rhythmogenesis across various stages of development and …