Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences
S Kato - Acta neuropathologica, 2008 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that
primarily involves the motor neuron system. The author initially summarizes the principal
features of human ALS neuropathology, and subsequently describes in detail ALS animal
models mainly from the viewpoint of pathological similarities and differences. ALS animal
models in this review include strains of rodents that are transgenic for superoxide dismutase
1 (SOD1), ALS2 knockout mice, and mice that are transgenic for cytoskeletal abnormalities …
primarily involves the motor neuron system. The author initially summarizes the principal
features of human ALS neuropathology, and subsequently describes in detail ALS animal
models mainly from the viewpoint of pathological similarities and differences. ALS animal
models in this review include strains of rodents that are transgenic for superoxide dismutase
1 (SOD1), ALS2 knockout mice, and mice that are transgenic for cytoskeletal abnormalities …
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