An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans

RC Crist, TK Clarke, A Ang… - …, 2013 - nature.com
… ), randomized opioid dependent patients to methadone or … genetic material and data on
treatment response (Saxon et al, … common OPRD1 genetic variants and treatment outcome in …

Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females

TK Clarke, RC Crist, A Ang… - The …, 2014 - nature.com
… located in intron 1, rs581111 and rs529520, predict treatment outcome in females … An
intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. …

A brief review of the genetics and pharmacogenetics of opioid use disorders

W Berrettini - Dialogues in clinical neuroscience, 2017 - Taylor & Francis
… why this effect is seen only among African Americans. This SNP … receptor gene (OPRD1)
had a substantial effect on therapeutic … intronic variant in OPRD1 predicts treatment outcome for …

Replication of the pharmacogenetic effect of rs678849 on buprenorphine efficacy in AfricanAmericans with opioid use disorder

RC Crist, KA Phillips, MA Furnari, LM Moran… - The …, 2019 - nature.com
… the effect of rs678849 on opioid use disorder treatment outcome … association between an
intronic variant in OPRD1 (rs678849) … to stratify patients based on predicted treatment efficacy. …

A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment

RC Crist, GA Doyle, KM Kampman… - … and alcohol dependence, 2016 - Elsevier
… of six OPRD1 variants in cocaine dependent individuals and … predicts the efficacy of methadone
and Suboxone in treatingdependence in African-Americans, the effect of the variant on …

[HTML][HTML] A review of the pharmacogenomics of buprenorphine for the treatment of opioid use disorder

HA Seguí, K Melin, DS Quiñones… - Journal of translational …, 2020 - ncbi.nlm.nih.gov
… an independent cohort of African Americans [48] . … treatment outcomes in OUD. The strongest
evidence to date shows an association with variants in intronic OPRD1 SNPs and treatment

The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients

PS Thomas Jr, EM Nielsen, CJ Spellicy… - Psychiatric …, 2021 - journals.lww.com
… use in African Americans treated with methadone. We … rs678849 genotype may predict
treatment response of disulfiram … for differences in treatment outcome in opioid-positive urines. …

OPRD1 SNPs associated with opioid addiction are cis-eQTLs for the phosphatase and actin regulator 4 gene, PHACTR4, a mediator of cytoskeletal dynamics

O Levran, M Randesi, M Adelson, MJ Kreek - Translational Psychiatry, 2021 - nature.com
… , and treatment outcome 10,19,20,21 , and is eQTL for OPRD1 … and African Americans) were
analyzed for OPRD1 haplotypes… to predict OD treatment response in African Americans, but …

Genetic Influences in Opioid Use Disorder

B Maher, J Rabinowitz - … Oxford Handbook of Opioids and Opioid …, 2023 - books.google.com
… 84 Moreover, although some work has shown that African Americans that were … An
intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. …

A polymorphism in the OPRM1 3′-untranslated region is associated with methadone efficacy in treating opioid dependence

RC Crist, GA Doyle, EC Nelson, L Degenhardt… - The …, 2018 - nature.com
… ′-UTR haplotypes and treatment outcome in opioid dependent European-Americans …
intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans