Analysis of cytogenetic effects in bone-marrow cells of rats subchronically exposed to smoke from cigarettes which burn or only heat tobacco
CK Lee, BG Brown, EA Reed, GD Lowe… - Mutation Research …, 1990 - Elsevier
The genotoxic effects of 90-day nose-only exposures to smoke from new cigarettes, which
heat but do not burn tobacco (New), or from reference cigarettes, which burn tobacco, were
evaluated in Sprague-Dawley rats by examining the cytogenetic endpoints of sister-
chromatid exchanges (SCE), chromosome aberrations, and micronuclei in bone-marrow
cells. The concentrations of wet total particulate matter (WTPM) and carbon monoxide in the
smoke from both cigarette types were similar. The mainstream smoke from both New and …
heat but do not burn tobacco (New), or from reference cigarettes, which burn tobacco, were
evaluated in Sprague-Dawley rats by examining the cytogenetic endpoints of sister-
chromatid exchanges (SCE), chromosome aberrations, and micronuclei in bone-marrow
cells. The concentrations of wet total particulate matter (WTPM) and carbon monoxide in the
smoke from both cigarette types were similar. The mainstream smoke from both New and …
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