Analysis of protein complexes using mass spectrometry
Nature reviews Molecular cell biology, 2007•nature.com
The versatile combination of affinity purification and mass spectrometry (AP–MS) has
recently been applied to the detailed characterization of many protein complexes and large
protein-interaction networks. The combination of AP–MS with other techniques, such as
biochemical fractionation, intact mass measurement and chemical crosslinking, can help to
decipher the supramolecular organization of protein complexes. AP–MS can also be
combined with quantitative proteomics approaches to better understand the dynamics of …
recently been applied to the detailed characterization of many protein complexes and large
protein-interaction networks. The combination of AP–MS with other techniques, such as
biochemical fractionation, intact mass measurement and chemical crosslinking, can help to
decipher the supramolecular organization of protein complexes. AP–MS can also be
combined with quantitative proteomics approaches to better understand the dynamics of …
Abstract
The versatile combination of affinity purification and mass spectrometry (AP–MS) has recently been applied to the detailed characterization of many protein complexes and large protein-interaction networks. The combination of AP–MS with other techniques, such as biochemical fractionation, intact mass measurement and chemical crosslinking, can help to decipher the supramolecular organization of protein complexes. AP–MS can also be combined with quantitative proteomics approaches to better understand the dynamics of protein–complex assembly.
nature.com
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