In the past few years, cell plasticity has emerged as a mode of targeted therapy evasion in
prostate adenocarcinoma. When exposed to anticancer therapies, tumor cells may switch
into a different histological subtype, such as the neuroendocrine phenotype which is
associated with treatment failure and a poor prognosis. In this study, we demonstrated that
long-term androgen signal depletion of prostate LNCaP cells induced a neuroendocrine
phenotype followed by re-differentiation towards a “stem-like” state. LNCaP cells incubated …