Patients with gender dysphoria are offered cross‐sex hormone therapy and sex
reassignment surgery to achieve the transition between the sex assigned at birth and
gender identity. According to international guidelines, cross‐sex hormone therapy in trans‐
women should lead to a psychologically and physiologically healthy body with feminized
serum hormone levels, resulting in suppression of spermatogenesis. However, in a recently
published multi‐center study, we discovered a high proportion of patients with male serum …