Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans
Pleurotus ostreatus is one of the widely cultivated edible mushrooms. Water-soluble
proteoglycan fractions from P. ostreatus mycelia were purified by alcohol-precipitation, ion
exchange and followed by gel permeation (Sephadex G-100) chromatography. Three
neutral fractions were found, which had polysaccharide to protein ratios 14.2, 26.4 and 18.3,
respectively. These fractions were tested for in vitro and in vivo immunomodulatory and
anticancer effects on Sarcoma-180-bearing mouse model. In vivo injection of proteoglycans …
proteoglycan fractions from P. ostreatus mycelia were purified by alcohol-precipitation, ion
exchange and followed by gel permeation (Sephadex G-100) chromatography. Three
neutral fractions were found, which had polysaccharide to protein ratios 14.2, 26.4 and 18.3,
respectively. These fractions were tested for in vitro and in vivo immunomodulatory and
anticancer effects on Sarcoma-180-bearing mouse model. In vivo injection of proteoglycans …
Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans.
IS Itisam Sarangi, DG Dipanjan Ghosh, SK Bhutia… - 2006 - cabidigitallibrary.org
Pleurotus ostreatus is one of the widely cultivated edible mushrooms. Water-soluble
proteoglycan fractions from P. ostreatus mycelia were purified by alcohol-precipitation, ion
exchange and followed by gel permeation (Sephadex G-100) chromatography. Three
neutral fractions were found, which had polysaccharide to protein ratios 14.2, 26.4 and 18.3,
respectively. These fractions were tested for in vitro and in vivo immunomodulatory and
anticancer effects on Sarcoma-180-bearing mouse model. In vivo injection of proteoglycans …
proteoglycan fractions from P. ostreatus mycelia were purified by alcohol-precipitation, ion
exchange and followed by gel permeation (Sephadex G-100) chromatography. Three
neutral fractions were found, which had polysaccharide to protein ratios 14.2, 26.4 and 18.3,
respectively. These fractions were tested for in vitro and in vivo immunomodulatory and
anticancer effects on Sarcoma-180-bearing mouse model. In vivo injection of proteoglycans …
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