Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants
BH Singsen, L Fishman, V Hanson - Pediatrics, 1976 - publications.aap.org
Drug-induced systemic lupus erythematosus (SLE)-like syndromes in children are most
commonly associated with the administration of ethosuximide, diphenylhydantoin, and
trimethadione. Five children receiving ethosuximide who presented with syndromes
suggestive of SLE were studied. Each had fever, malar rash, arthritis, and lymphadenopathy.
Two children had pleural effusions and another developed myocarditis and pericarditis.
Three patients had anti-DNA antibodies associated with low serum C3. In four of five …
commonly associated with the administration of ethosuximide, diphenylhydantoin, and
trimethadione. Five children receiving ethosuximide who presented with syndromes
suggestive of SLE were studied. Each had fever, malar rash, arthritis, and lymphadenopathy.
Two children had pleural effusions and another developed myocarditis and pericarditis.
Three patients had anti-DNA antibodies associated with low serum C3. In four of five …
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