Antitumoral properties and reduced toxicity of LPS targeted to macrophages via normal or mannosylated liposomes.
S Dumont, CD Muller, F Schuber… - Anticancer …, 1990 - europepmc.org
Neo-mannosylated liposomes have been prepared by coupling a mannose derivative
bearing a hydrophilic spacer arm to preformed large unilamellar liposomes containing 4-(p-
maleimidophenyl) butyryl-phosphatidylethanolamine. Lipopolysaccharide (LPS) was
encapsulated in normal or neo-mannosylated liposomes; the neo-mannosylated vesicles
showed specificity for the in vitro activation to toxicity of macrophages only in the case of
differentiated macrophages presenting mannose receptors at their surface. In vivo, LPS …
bearing a hydrophilic spacer arm to preformed large unilamellar liposomes containing 4-(p-
maleimidophenyl) butyryl-phosphatidylethanolamine. Lipopolysaccharide (LPS) was
encapsulated in normal or neo-mannosylated liposomes; the neo-mannosylated vesicles
showed specificity for the in vitro activation to toxicity of macrophages only in the case of
differentiated macrophages presenting mannose receptors at their surface. In vivo, LPS …
