Antivirus and immune enhancement activities of sulfated polysaccharide from Angelica sinensis

T Yang, M Jia, S Zhou, F Pan, Q Mei - International Journal of Biological …, 2012 - Elsevier
This study is to synthesize sulfated Angelica polysaccharides (APSs) and investigate the
activity of one of the sulfated derivatives APS-1 on murine leukemia virus in vivo. Six sulfated
derivatives with degree of sulfation ranging from 0.68 to 1.91 were obtained. And the virus
replication was inhibited by APS-1 at the dose of 10 and 30mg/kg (26% and 30% inhibition
respectively). Furthermore, both the percentage of CD4+ cells and CD4+/CD8+ ratio in
peripheral blood cells were significantly enhanced by APS-1 at 3–30mg/kg. In addition, the …

Antivirus and immune enhancement activities of sulfated polysaccharide from Angelica sinensis.

YTH Yang TieHong, JM Jia Min, ZSY Zhou SiYuan… - 2012 - cabidigitallibrary.org
This study is to synthesize sulfated Angelica polysaccharides (APSs) and investigate the
activity of one of the sulfated derivatives APS-1 on murine leukemia virus in vivo. Six sulfated
derivatives with degree of sulfation ranging from 0.68 to 1.91 were obtained. And the virus
replication was inhibited by APS-1 at the dose of 10 and 30 mg/kg (26% and 30% inhibition
respectively). Furthermore, both the percentage of CD4+ cells and CD4+/CD8+ ratio in
peripheral blood cells were significantly enhanced by APS-1 at 3-30 mg/kg. In addition, the …
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