Antizyme delays the restoration by spermine of growth of polyamine-deficient cells through its negative regulation of polyamine transport
Y He, T Suzuki, K Kashiwagi, K Igarashi - Biochemical and biophysical …, 1994 - Elsevier
Abstract Effects of antizyme on polyamine transport and spermine restoration of the growth
of polyamine-deficient cells were examined by using mouse FM3A cells transfected with
pMAMneoZ1 possessing rat antizyme cDNA under the control of glucocorticoid-inducible
promoter. Treatments of the transfected cells with α-difluoromethylornithine (DFMO), an
inhibitor of ornithine decarboxylase (ODC), and dexamethasone, an inducer of antizyme,
both caused a decrease in ODC activity and polyamine contents and inhibition of cell …
of polyamine-deficient cells were examined by using mouse FM3A cells transfected with
pMAMneoZ1 possessing rat antizyme cDNA under the control of glucocorticoid-inducible
promoter. Treatments of the transfected cells with α-difluoromethylornithine (DFMO), an
inhibitor of ornithine decarboxylase (ODC), and dexamethasone, an inducer of antizyme,
both caused a decrease in ODC activity and polyamine contents and inhibition of cell …
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