Application and assessment of a regular environmental monitoring of the antineoplastic drug contamination level in pharmacies-the MEWIP project

TK Kiffmeyer, J Tuerk, M Hahn… - Annals of …, 2013 - academic.oup.com
TK Kiffmeyer, J Tuerk, M Hahn, H Stuetzer, C Hadtstein, A Heinemann, U Eickmann
Annals of occupational hygiene, 2013academic.oup.com
A large-scale study was carried out in order to determine the contamination level of
antineoplastic drugs in pharmacies and to investigate the suitability and effects of wipe
sample monitoring at regular intervals. A specific study design was developed. The 130
participating pharmacies were divided into a study and a control group, carrying out five and
two wipe sampling cycles, respectively. The work practice was analyzed using
questionnaires to identify factors that influence the contamination level. From 1269 wipe …
Abstract
A large-scale study was carried out in order to determine the contamination level of antineoplastic drugs in pharmacies and to investigate the suitability and effects of wipe sample monitoring at regular intervals. A specific study design was developed. The 130 participating pharmacies were divided into a study and a control group, carrying out five and two wipe sampling cycles, respectively. The work practice was analyzed using questionnaires to identify factors that influence the contamination level. From 1269 wipe samples, 774 (61%) were contaminated with at least one of the analyzed cytotoxic drugs: cyclophosphamide, docetaxel, etoposide, 5-fluorouracil, gemcitabine, ifosfamide, methotrexate, and paclitaxel. A significant decrease of the contamination with cyclophosphamide and 5-fluorouracil was observed in the study group. The Monitoring-Effect Study of Wipe Sampling in Pharmacies method has proven to be a reliable and affordable tool for contamination control. Based on the 90th percentile of the contamination values, a substance-independent performance-based guidance value of 0.1ng cm-2 has been derived.
Oxford University Press
以上显示的是最相近的搜索结果。 查看全部搜索结果