Application of OECD Guideline 423 in assessing the acute oral toxicity of moniliformin
M Jonsson, M Jestoi, AV Nathanail… - Food and chemical …, 2013 - Elsevier
Moniliformin is a Fusarium mycotoxin highly prevalent in grains and grain-based products
worldwide. In this study, the acute oral toxicity of moniliformin was assessed in Sprague–
Dawley male rats according to OECD Guideline 423 with a single-dose exposure. Clinical
observations and histopathological changes were recorded together with the excretion of
moniliformin via urine and feces, utilizing a novel liquid chromatography–mass spectrometry
method. According to our study, moniliformin is acutely toxic to rats with a rather narrow …
worldwide. In this study, the acute oral toxicity of moniliformin was assessed in Sprague–
Dawley male rats according to OECD Guideline 423 with a single-dose exposure. Clinical
observations and histopathological changes were recorded together with the excretion of
moniliformin via urine and feces, utilizing a novel liquid chromatography–mass spectrometry
method. According to our study, moniliformin is acutely toxic to rats with a rather narrow …
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