Assessing effects of treatment with lisdexamfetamine dimesylate for pediatric ADHD using a parental survey

D Antonucci, C Kunins, M Manos, FA López… - CNS …, 2010 - cambridge.org
D Antonucci, C Kunins, M Manos, FA López, DL Kerney
CNS spectrums, 2010cambridge.org
Introduction: Lisdexamfetamine dimesylate (LDX) is a prodrug stimulant approved for the
treatment of attention-deficit/hyperactivity disorder (ADHD) in adults and children 6–12 years
of age. Parent surveys provide valuable information regarding the impact of ADHD
treatments. Methods: Parents of children with ADHD beginning treatment with LDX
voluntarily completed surveys through an automated telephone system or the Internet before
and 6 weeks after LDX treatment initiation. Prescribing physicians received individual …
Introduction
Lisdexamfetamine dimesylate (LDX) is a prodrug stimulant approved for the treatment of attention-deficit/hyperactivity disorder (ADHD) in adults and children 6–12 years of age. Parent surveys provide valuable information regarding the impact of ADHD treatments.
Methods
Parents of children with ADHD beginning treatment with LDX voluntarily completed surveys through an automated telephone system or the Internet before and 6 weeks after LDX treatment initiation. Prescribing physicians received individual reports of the responses for each survey completed by their patients' parents. All patients whose parents completed both baseline and 6 week surveys were included in the analyses. Subgroup analyses were conducted for those previously treated with medications to treat ADHD, including mixed amphetamine salts-extended release.
Results
LDX treatment was associated with a significant decrease in ADHD symptom interference with school activities, family interactions, homework, and social interactions (P<.01; N= 11,576). Parents rated satisfaction with LDX as significantly higher than with their child's previous treatment (P<.01). On average, global improvement, tolerability, convenience, and satisfaction with LDX were all highly rated.
Conclusion
Patients treated with LDX showed significant symptom improvement and parents reported significantly greater satisfaction than with prior treatment.
Cambridge University Press
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