Assessment of central blood pressure in patients with type 2 diabetes: a comparison between SphygmoCor and invasively measured values
E Laugesen, NB Rossen, CD Peters… - American journal of …, 2014 - academic.oup.com
E Laugesen, NB Rossen, CD Peters, M Mæng, E Ebbehøj, ST Knudsen, KW Hansen…
American journal of hypertension, 2014•academic.oup.comBACKGROUND The SphygmoCor is used for noninvasive assessment of ascending aortic
blood pressure (BP). However, the validity of the SphygmoCor transfer function has not been
tested in an exclusively type 2 diabetic patient sample. Calibration with systolic (SBP) and
diastolic (DBP) brachial BP has previously been associated with substantial imprecision of
central BP estimates. We hypothesized that different noninvasive calibration strategies might
improve the accuracy of the estimated ascending aortic BPs. METHODS In 34 patients with …
blood pressure (BP). However, the validity of the SphygmoCor transfer function has not been
tested in an exclusively type 2 diabetic patient sample. Calibration with systolic (SBP) and
diastolic (DBP) brachial BP has previously been associated with substantial imprecision of
central BP estimates. We hypothesized that different noninvasive calibration strategies might
improve the accuracy of the estimated ascending aortic BPs. METHODS In 34 patients with …
BACKGROUND
The SphygmoCor is used for noninvasive assessment of ascending aortic blood pressure (BP). However, the validity of the SphygmoCor transfer function has not been tested in an exclusively type 2 diabetic patient sample. Calibration with systolic (SBP) and diastolic (DBP) brachial BP has previously been associated with substantial imprecision of central BP estimates. We hypothesized that different noninvasive calibration strategies might improve the accuracy of the estimated ascending aortic BPs.
METHODS
In 34 patients with type 2 diabetes we estimated ascending aortic SBP and DBP using the SphygmoCor device and compared these data with invasively recorded data. The validity of the transfer function was assessed by calibrating with invasively recorded DBP and mean BP (MBP). The influence of noninvasive calibration strategies was assessed by calibrating with brachial oscillometric SBP+DBP vs. DBP+MBP using a form factor (ff) of 0.33 and 0.40, respectively.
RESULTS
When calibrating with invasive BP, the difference between estimated and invasively measured ascending aortic SBP and DBP was −2.3±5.6/1.0±0.9mm Hg. When calibrating with oscillometric brachial BPs, the differences were −9.6±8.1/14.1±6.2mm Hg (calibration with SBP and DBP), −8.3±11.7/13.9±6.1mm Hg (DBP and MBP; ff = 0.33), and 1.9±12.2/14.1±6.2mm Hg (DBP and MBP; ff = 0.40), respectively. Calibration with the average of 3 brachial BPs did not improve accuracy.
CONCLUSIONS
The SphygmoCor transfer function seems valid in patients with type 2 diabetes. Noninvasive calibration with DBP and MBP (ff = 0.40) enables accurate estimation of mean ascending aortic SBP at the group level. However, the wide limits of agreement indicate limited accuracy in the individual patient.
CLINICAL TRIALS REGISTRATION
Clinical Trials No. NCT01538290.
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