Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region
D Schonk, P Van Dijk, P Riegmann… - … and Genome Research, 1990 - karger.com
D Schonk, P Van Dijk, P Riegmann, J Trapman, C Holm, TC Willcocks, P Sillekens…
Cytogenetic and Genome Research, 1990•karger.comHybridization studies using a panel of somatic cell hybrids with subchromosomal segments
of 19q have localized the genes encoding hormone-sensitive lipase (LIPE),
carcinoembryonic antigen (CEA), and small nuclear ribonucleoprotein polypeptide A
(SNRPA) to various regions of 19q13. 1; the cellular receptor for poliovirus sensitivity (PVS)
to 19ql3. 2; and the genes coding for prostate-specific antigen (APS), human pancreatic
kallikrein (KLK1), and small nuclear ribonucleoprotein 70-kD poly-peptide (SNRP70) to 19q …
of 19q have localized the genes encoding hormone-sensitive lipase (LIPE),
carcinoembryonic antigen (CEA), and small nuclear ribonucleoprotein polypeptide A
(SNRPA) to various regions of 19q13. 1; the cellular receptor for poliovirus sensitivity (PVS)
to 19ql3. 2; and the genes coding for prostate-specific antigen (APS), human pancreatic
kallikrein (KLK1), and small nuclear ribonucleoprotein 70-kD poly-peptide (SNRP70) to 19q …
Abstract
Hybridization studies using a panel of somatic cell hybrids with subchromosomal segments of 19q have localized the genes encoding hormone-sensitive lipase (LIPE), carcinoembryonic antigen (CEA), and small nuclear ribonucleoprotein polypeptide A (SNRPA) to various regions of 19q13.1; the cellular receptor for poliovirus sensitivity (PVS) to 19ql3.2; and the genes coding for prostate-specific antigen (APS), human pancreatic kallikrein (KLK1), and small nuclear ribonucleoprotein 70-kD poly-peptide (SNRP70) to 19q 13.3 →qter. Our results exclude several of these genes from being seriously considered as a candidate for the myotonic dystrophy gene on 19q.
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