Association between Fetal MTHFR A1298C (rs1801131) Polymorphism and Neural Tube Defects Risk: A Systematic Review and Meta-Analysis
S Soleimani-Jadidi, B Meibodi, A Javaheri… - Fetal and Pediatric …, 2022 - Taylor & Francis
Fetal and Pediatric Pathology, 2022•Taylor & Francis
Background The association of the fetal MTHFR A1298C (rs1801131) polymorphism and
neural tube defects (NTDs) susceptibility has been widely demonstrated, but the results
remain inconclusive. Thus, we performed a meta-analysis to investigate the association
between fetal MTHFR A1298C polymorphism and NTDs risk. Methods An electronic search
of PubMed, web of science, SciELO, CNKI database for studies on the fetal MTHFR A1298C
polymorphism and NTDs risk was performed up to March 30, 2020. Results A total of 22 …
neural tube defects (NTDs) susceptibility has been widely demonstrated, but the results
remain inconclusive. Thus, we performed a meta-analysis to investigate the association
between fetal MTHFR A1298C polymorphism and NTDs risk. Methods An electronic search
of PubMed, web of science, SciELO, CNKI database for studies on the fetal MTHFR A1298C
polymorphism and NTDs risk was performed up to March 30, 2020. Results A total of 22 …
Background
The association of the fetal MTHFR A1298C (rs1801131) polymorphism and neural tube defects (NTDs) susceptibility has been widely demonstrated, but the results remain inconclusive. Thus, we performed a meta-analysis to investigate the association between fetal MTHFR A1298C polymorphism and NTDs risk.
Methods
An electronic search of PubMed, web of science, SciELO, CNKI database for studies on the fetal MTHFR A1298C polymorphism and NTDs risk was performed up to March 30, 2020.
Results
A total of 22 case-control studies with 3,224 fetuses with NTDs and 3,295 controls were selected. Overall, pooled data showed that the fetal MTHFR A1298C polymorphism was not significantly associated with risk an increased risk of NTDs in the global population. When stratified analysis by ethnicity, country of origin and NTDs type, still no statistically significant association was found.
Conclusions
Our pooled data emerged no evidence for significant association between fetal MTHFR A1298C polymorphism and NTDs risk.
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