Association of early-onset Alzheimer disease with elevated low-density lipoprotein cholesterol levels and rare genetic coding variants of APOB
Importance Early-onset Alzheimer disease (EOAD) is a rare form of Alzheimer disease (AD)
with a large genetic basis that is only partially understood. In late-onset AD, elevated
circulating cholesterol levels increase AD risk even after adjusting for the apolipoprotein E
ε4 (APOE E4) allele, a major genetic factor for AD and elevated cholesterol levels; however,
the role of circulating cholesterol levels in EOAD is unclear. Objectives To investigate the
association between circulating cholesterol levels and EOAD and to identify genetic variants …
with a large genetic basis that is only partially understood. In late-onset AD, elevated
circulating cholesterol levels increase AD risk even after adjusting for the apolipoprotein E
ε4 (APOE E4) allele, a major genetic factor for AD and elevated cholesterol levels; however,
the role of circulating cholesterol levels in EOAD is unclear. Objectives To investigate the
association between circulating cholesterol levels and EOAD and to identify genetic variants …
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