Association of fitness and grip strength with heart failure: findings from the UK Biobank population-based study

A Sillars, CA Celis-Morales, FK Ho, F Petermann… - Mayo Clinic …, 2019 - Elsevier
Mayo Clinic Proceedings, 2019Elsevier
Objective To investigate the associations of objectively measured cardiorespiratory fitness
(CRF) and grip strength (GS) with incident heart failure (HF), a clinical syndrome that results
in substantial social and economic burden, using UK Biobank data. Patients and Methods Of
the 502,628 participants recruited into the UK Biobank between April 1, 2007, and
December 31, 2010, a total of 374,493 were included in our GS analysis and 57,053 were
included in CRF analysis. Associations between CRF and GS and incident HF were …
Objective
To investigate the associations of objectively measured cardiorespiratory fitness (CRF) and grip strength (GS) with incident heart failure (HF), a clinical syndrome that results in substantial social and economic burden, using UK Biobank data.
Patients and Methods
Of the 502,628 participants recruited into the UK Biobank between April 1, 2007, and December 31, 2010, a total of 374,493 were included in our GS analysis and 57,053 were included in CRF analysis. Associations between CRF and GS and incident HF were investigated using Cox proportional hazard models, with adjustment for known measured confounders.
Results
During a mean of 4.1 (range, 2.4-7.1) years, 631 HF events occurred in those with GS data, and 66 HF events occurred in those with CRF data. Higher CRF was associated with 18% lower risk for HF (hazard ratio [HR], 0.82; 95% CI, 0.76-0.88) per 1–metabolic equivalent increment increase and GS was associated with 19% lower incidence of HF risk (HR, 0.81; 95% CI, 0.77-0.86) per 5-kg increment increase. When CRF and GS were standardized, the HR for CRF was 0.50 per 1-SD increment (95% CI, 0.38-0.65), and for GS was 0.65 per 1-SD increment (95% CI, 0.58-0.72).
Conclusion
Our data indicate that objective measurements of physical function (GS and CRF) are strongly and independently associated with lower HF incidence. Future studies targeting improving CRF and muscle strength should include HF as an outcome to assess whether these results are causal.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果