Attenuation of scopolamine-induced cognitive dysfunction by obovatol
DY Choi, YJ Lee, SY Lee, YM Lee, HH Lee… - Archives of pharmacal …, 2012 - Springer
DY Choi, YJ Lee, SY Lee, YM Lee, HH Lee, IS Choi, KW Oh, SB Han, SY Nam, JT Hong
Archives of pharmacal research, 2012•SpringerAlzheimer's disease (AD) is the most prevalent cause of dementia in the elderly people. The
disease is pathologically characterized by extracellular deposition of beta-amyloid peptide
(Aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (AChE) activity
in the affected regions. In this study, we investigated the effects of obovatol on memory
dysfunction, which was caused by scopolamine. Obovatol (0.2, 0.5 and 1 mg/kg for 7 day)
attenuated scopolamine (1 mg/kg, ip)-induced amnesia in a dose-dependent manner, as …
disease is pathologically characterized by extracellular deposition of beta-amyloid peptide
(Aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (AChE) activity
in the affected regions. In this study, we investigated the effects of obovatol on memory
dysfunction, which was caused by scopolamine. Obovatol (0.2, 0.5 and 1 mg/kg for 7 day)
attenuated scopolamine (1 mg/kg, ip)-induced amnesia in a dose-dependent manner, as …
Abstract
Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly people. The disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (Aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (AChE) activity in the affected regions. In this study, we investigated the effects of obovatol on memory dysfunction, which was caused by scopolamine. Obovatol (0.2, 0.5 and 1 mg/kg for 7 day) attenuated scopolamine (1 mg/kg, i.p.)-induced amnesia in a dose-dependent manner, as revealed by the Morris water maze test and step-through passive avoidance test. Mechanism studies exhibited that obovatol dose-dependently alleviated scopolamine-induced increase in Aβ generation and β-secretase activity in the cortex and hippocampus. Obovatol also attenuated scopolamine-induced rise in AChE activity in the cortex and hippocampus. Obovatol might rescue scopolamine-mediated impaired learning and memory function by attenuating Aβ accumulation and stabilizing cholinergic neurotransmission, which suggests that the natural compound could be a useful agent for the prevention of the development or progression of AD neurodegeneration.
Springer
以上显示的是最相近的搜索结果。 查看全部搜索结果