BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors
M Watanabe, YJ Kang, LM Davies… - Journal of …, 2012 - Soc Neuroscience
Choroid plexus epithelial cells (CPECs) have essential developmental and homeostatic
roles related to the CSF and blood–CSF barrier they produce. Accordingly, CPEC
dysfunction has been implicated in many neurological disorders, such as Alzheimer9s
disease, and transplant studies have provided proof-of-concept for CPEC-based therapies.
However, such therapies have been hindered by the inability to expand or generate CPECs
in culture. During development, CPECs differentiate from preneurogenic neuroepithelial …
roles related to the CSF and blood–CSF barrier they produce. Accordingly, CPEC
dysfunction has been implicated in many neurological disorders, such as Alzheimer9s
disease, and transplant studies have provided proof-of-concept for CPEC-based therapies.
However, such therapies have been hindered by the inability to expand or generate CPECs
in culture. During development, CPECs differentiate from preneurogenic neuroepithelial …
以上显示的是最相近的搜索结果。 查看全部搜索结果