Bioavailability and tolerability of combination treatment with revaprazan 200 mg+ itopride 150 mg: a randomized crossover study in healthy male Korean volunteers
HY Choi, YH Noh, SJ Jin, YH Kim, MJ Kim, H Sung… - Clinical …, 2012 - Elsevier
BACKGROUND: To date, no definitive treatment of functional dyspepsia (FD) has been
proven to be effective and reasonably well-tolerated. Proton pump inhibitors (PPIs)
combined with prokinetic agents are considered an effective option. Revaprazan is a
selective potassium-competitive acid blocker that reversibly inhibits gastric H+/K+-ATPase
and shows effective acid suppression comparable to PPIs. Itopride is a prokinetic agent that
has anticholinesterase activity as well as dopamine D2 receptor antagonistic activity. For this …
proven to be effective and reasonably well-tolerated. Proton pump inhibitors (PPIs)
combined with prokinetic agents are considered an effective option. Revaprazan is a
selective potassium-competitive acid blocker that reversibly inhibits gastric H+/K+-ATPase
and shows effective acid suppression comparable to PPIs. Itopride is a prokinetic agent that
has anticholinesterase activity as well as dopamine D2 receptor antagonistic activity. For this …
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