Biocompatibility studies of modified collagen/Hyaluronan membranes after implantation
J Koller, D Bakoš, I Sadloňová - Cell and Tissue Banking, 2001 - Springer
J Koller, D Bakoš, I Sadloňová
Cell and Tissue Banking, 2001•SpringerTwo varieties of collagen/sodium hyaluronan membranes were used asdermal substitutes in
a biocompatibility implantation study on rats. In orderto improve especially the physical and
mechanical properties of the material, themembranes were chemically modified using a
combination ofhexamethylenediisocyanate (HMDC) as a crosslinker and polyoxy-ethylene
(POE) asa spacer. According to both macroscopic and microscopic histologicalobservations,
the membranes were well accepted by the surrounding host tissuein all the animals. No …
a biocompatibility implantation study on rats. In orderto improve especially the physical and
mechanical properties of the material, themembranes were chemically modified using a
combination ofhexamethylenediisocyanate (HMDC) as a crosslinker and polyoxy-ethylene
(POE) asa spacer. According to both macroscopic and microscopic histologicalobservations,
the membranes were well accepted by the surrounding host tissuein all the animals. No …
Abstract
Two varieties of collagen/sodium hyaluronan membranes were used asdermal substitutes in a biocompatibility implantation study on rats. In orderto improve especially the physical and mechanical properties of the material, themembranes were chemically modified using a combination ofhexamethylenediisocyanate (HMDC) as a crosslinker and polyoxy-ethylene (POE) asa spacer. According to both macroscopic and microscopic histologicalobservations, the membranes were well accepted by the surrounding host tissuein all the animals. No major differences in relation to the outgrowth of thematerial by host tissue have been observed between the implant varieties A andB. The most important finding was that no pathological changes or importantalterations of the host tissues were detected.
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