Biological heterogeneity in ADNI amnestic mild cognitive impairment
Background Previous work examining normal controls from the Alzheimer's Disease
Neuroimaging Initiative (ADNI) identified substantial biological heterogeneity. We
hypothesized that ADNI mild cognitive impairment (MCI) subjects would also exhibit
heterogeneity with possible clinical implications. Methods ADNI subjects diagnosed with
amnestic MCI (n= 138) were clustered based on baseline magnetic resonance imaging,
cerebrospinal fluid, and serum biomarkers. The clusters were compared with respect to …
Neuroimaging Initiative (ADNI) identified substantial biological heterogeneity. We
hypothesized that ADNI mild cognitive impairment (MCI) subjects would also exhibit
heterogeneity with possible clinical implications. Methods ADNI subjects diagnosed with
amnestic MCI (n= 138) were clustered based on baseline magnetic resonance imaging,
cerebrospinal fluid, and serum biomarkers. The clusters were compared with respect to …
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