Biphasic expression and cytokine regulation of the complement C3 in heart allograft

W Wu, H Wang, P He, Y Zhang, K Yang, X Hua - Transplant Immunology, 2011 - Elsevier
Locally synthesized complement may play a more important role in regulating antigen-
specific immune response than circulating complement; however, complement production in
transplanted heart remains obscure. In the current study, we investigated local production of
the complement C3 in mouse cardiac allografts and examined the relationship between C3
production and cytokine expression. The cardiac grafts of allogeneic (C57BL/6–BALB/c
mice) and syngeneic mouse models were subjected to histopathological and …
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