Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy
H Yang, T Dong, E Turnbull, S Ranasinghe… - The Journal of …, 2007 - journals.aai.org
During chronic HIV-1 infection, continuing viral replication is associated with impaired
proliferative capacity of virus-specific CD8+ T cells and with the expansion and persistence
of oligoclonal T cell populations. TCR usage may significantly influence CD8+ T cell-
mediated control of AIDS viruses; however, the potential to modulate the repertoire of
functional virus-specific T cells by immunotherapy has not been explored. To investigate
this, we analyzed the TCR Vβ usage of CD8+ T cells populations which were expanded …
proliferative capacity of virus-specific CD8+ T cells and with the expansion and persistence
of oligoclonal T cell populations. TCR usage may significantly influence CD8+ T cell-
mediated control of AIDS viruses; however, the potential to modulate the repertoire of
functional virus-specific T cells by immunotherapy has not been explored. To investigate
this, we analyzed the TCR Vβ usage of CD8+ T cells populations which were expanded …
Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy.
YHB Yang HongBing, DT Dong Tao, E Turnbull… - 2007 - cabidigitallibrary.org
During chronic HIV-1 infection, continuing viral replication is associated with impaired
proliferative capacity of virus-specific CD8+ T cells and with the expansion and persistence
of oligodonal T cell populations. TCR usage may significantly influence CD8+ T cell-
mediated control of AIDS viruses; however, the potential to modulate the repertoire of
functional virus-specific T cells by immunotherapy has not been explored. To investigate
this, we analyzed the TCR Vβ usage of CD8+ T cells populations which were expanded …
proliferative capacity of virus-specific CD8+ T cells and with the expansion and persistence
of oligodonal T cell populations. TCR usage may significantly influence CD8+ T cell-
mediated control of AIDS viruses; however, the potential to modulate the repertoire of
functional virus-specific T cells by immunotherapy has not been explored. To investigate
this, we analyzed the TCR Vβ usage of CD8+ T cells populations which were expanded …
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