C3435T polymorphism of MDR1 gene with warfarin resistance

Y Kim, A Smith, AHB Wu - Clinica Chimica Acta, 2013 - Elsevier
Y Kim, A Smith, AHB Wu
Clinica Chimica Acta, 2013Elsevier
Background Some patients show warfarin resistance needing more than 70 mg of warfarin
per week. In this study, we examined if C3435T polymorphism of MDR1 gene could be a
factor of warfarin resistance. Methods We examined 196 blood specimens from the patients
who took warfarin more than 42 mg/week for at least 1 year. The subjects consisted of 74
European Americans, 59 African Americans, 42 Hispanic Americans and 21 Asian
Americans. Genotype of C3435T polymorphism was determined by using real-time …
Background
Some patients show warfarin resistance needing more than 70 mg of warfarin per week. In this study, we examined if C3435T polymorphism of MDR1 gene could be a factor of warfarin resistance.
Methods
We examined 196 blood specimens from the patients who took warfarin more than 42 mg/week for at least 1 year. The subjects consisted of 74 European Americans, 59 African Americans, 42 Hispanic Americans and 21 Asian Americans. Genotype of C3435T polymorphism was determined by using real-time polymerase chain reaction (PCR).
Results
Ninety (45.9%) of the 196 patients had C3435T genotype and the remaining patients had C3435C genotype (35.7%) and T3435T genotype (18.4%). Mean dose of warfarin of patients with C3435C, C3435T and T3435T genotypes were 59.5 mg/week, 56.9 mg/week and 55.6 mg/week, respectively. There was no statistical difference in the dose of warfarin between the 3 genotypes within each race.
Conclusion
Our results suggest that C3435T polymorphism of MDR1 gene is not associated with warfarin resistance.
Elsevier
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