CD5 (Ly-1)-negative, conventional splenic B cells make a substantial contribution to the bromelain plaque-forming cell response in CBA and BW mice.

EM Andrew, W Annis, M Kahan, RN Maini - Immunology, 1990 - ncbi.nlm.nih.gov
EM Andrew, W Annis, M Kahan, RN Maini
Immunology, 1990ncbi.nlm.nih.gov
Abstract CD5 (Ly-1) B cells are a minor subpopulation in mouse spleen and are thought to
be responsible for the production of natural autoantibodies to bromelain-treated autologous
erythrocytes (Br-RBC). Here it is shown that substantial numbers of conventional, CD5-
negative, splenic B cells also secrete these antibodies in CBA and (NZB x NZW) F1 mice,
whereas in NZB and BALB/c mice they are all produced by the CD5 B-cell population.
However, stimulation with bacterial lipopolysaccharide in vivo preferentially activates the …
Abstract
CD5 (Ly-1) B cells are a minor subpopulation in mouse spleen and are thought to be responsible for the production of natural autoantibodies to bromelain-treated autologous erythrocytes (Br-RBC). Here it is shown that substantial numbers of conventional, CD5-negative, splenic B cells also secrete these antibodies in CBA and (NZB x NZW) F1 mice, whereas in NZB and BALB/c mice they are all produced by the CD5 B-cell population. However, stimulation with bacterial lipopolysaccharide in vivo preferentially activates the CD5 B-cell group to anti-Br-RBC antibody secretion.
ncbi.nlm.nih.gov
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