CYP2B6 and OPRM1 gene variations predict methadone‐related deaths
H Bunten, WJ Liang, D Pounder… - Addiction …, 2011 - Wiley Online Library
The largest proportion of methadone‐associated deaths occurs during the drug induction
phase. We analysed methadone‐related fatalities for gene variations linked with methadone
action. A significant association between high methadone concentrations and the CYP2B6*
6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the
risk of methadone fatality may be predetermined in part by the CYP2B6* 6 allele. A
significant correlation was also observed between post‐mortem benzodiazepine …
phase. We analysed methadone‐related fatalities for gene variations linked with methadone
action. A significant association between high methadone concentrations and the CYP2B6*
6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the
risk of methadone fatality may be predetermined in part by the CYP2B6* 6 allele. A
significant correlation was also observed between post‐mortem benzodiazepine …
以上显示的是最相近的搜索结果。 查看全部搜索结果