Calcium mobilization and phosphatidylinositol turnover in vas deferens smooth muscle of diabetic rats
Y Sakai, K Aihara, H Honda, M Inazu - European journal of pharmacology, 1989 - Elsevier
The study concerned Ca 2+ channels that are receptor-operated by norepinephrine (NE)
and mediate hyper-reactivity of vas deferens smooth muscle from rats with streptozotocin
(STZ)-induced diabetes, and the mediatory responses of these channels, such as tension
development, Ca 2+ uptake and phosphatidylinositol (PI) turnover. The contractile
responses induced by adrenoceptor agonists were significantly greater in diabetic rat vas
deferens than in the controls. A greater Ca 2+ uptake was induced by 10− 5 M NE in strips …
and mediate hyper-reactivity of vas deferens smooth muscle from rats with streptozotocin
(STZ)-induced diabetes, and the mediatory responses of these channels, such as tension
development, Ca 2+ uptake and phosphatidylinositol (PI) turnover. The contractile
responses induced by adrenoceptor agonists were significantly greater in diabetic rat vas
deferens than in the controls. A greater Ca 2+ uptake was induced by 10− 5 M NE in strips …
