Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane …

T Nishimura, M Mitsunaga, K Ito, H Kobayashi… - Gastric Cancer, 2020 - Springer
Background Near-infrared photoimmunotherapy (NIR-PIT) constitutes a new class of
molecular-targeted theranostics utilizing monoclonal antibody (mAb)-photosensitizer
conjugates and NIR light. In this study, we developed a new type of NIR-PIT targeting
vascular endothelial growth factor receptor 2 (VEGFR-2) expressed on vascular
endothelium in an experimental gastric cancer model and evaluated the feasibility by
comparing conventional NIR-PIT targeting cancer cell membrane in vitro and in vivo …

[引用][C] Cancer neovasculature-targeted near‑infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell …

西村尚 - Gastric cancer: official journal of the International … - ir.jikei.ac.jp
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