Cell uptake and cytotoxicity of a novel cyclometalated iridium (III) complex and its octaarginine peptide conjugate
C Dolan, RD Moriarty, E Lestini, M Devocelle… - Journal of Inorganic …, 2013 - Elsevier
The synthesis and characterisation of iridium (III) bis (2-(2, 4-difluorophenyl) pyridinato-N,
C2′)-2 (4-carboxylphenyl) imidazo [4, 5-f][1, 10] phenanthroline perchlorate,[Ir (dfpp) 2
(picCOOH)]+ and its octaarginine conjugate [Ir (dfpp) 2 (picCONH-Arg8)] 9+ are reported.
Both complex and conjugate exhibit intense and long-lived luminescence, which is O2 and
pH sensitive. Conjugation to the polyarginine peptide renders the complex very water
soluble. The uptake of the parent iridium (III) complex and conjugate are compared in two …
C2′)-2 (4-carboxylphenyl) imidazo [4, 5-f][1, 10] phenanthroline perchlorate,[Ir (dfpp) 2
(picCOOH)]+ and its octaarginine conjugate [Ir (dfpp) 2 (picCONH-Arg8)] 9+ are reported.
Both complex and conjugate exhibit intense and long-lived luminescence, which is O2 and
pH sensitive. Conjugation to the polyarginine peptide renders the complex very water
soluble. The uptake of the parent iridium (III) complex and conjugate are compared in two …
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