Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock
K Saukkonen, P Lakkisto, V Pettila, M Varpula… - Clinical …, 2008 - academic.oup.com
Background: Increased concentrations of cell-free DNA have been found in plasma of septic
and critically ill patients. We investigated the value of plasma DNA for the prediction of
intensive care unit (ICU) and hospital mortality and its association with the degree of organ
dysfunction and disease severity in patients with severe sepsis. Methods: We studied 255
patients with severe sepsis or septic shock. We obtained blood samples on the day of study
inclusion and 72 h later and measured cell-free plasma DNA by real-time quantitative PCR …
and critically ill patients. We investigated the value of plasma DNA for the prediction of
intensive care unit (ICU) and hospital mortality and its association with the degree of organ
dysfunction and disease severity in patients with severe sepsis. Methods: We studied 255
patients with severe sepsis or septic shock. We obtained blood samples on the day of study
inclusion and 72 h later and measured cell-free plasma DNA by real-time quantitative PCR …
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