Cellular immune responses in the murine lung to local immunization with influenza A virus glycoproteins in micelles and immunostimulatory complexes (iscoms)
PD Jones, R ThaHla, B Morein… - Scandinavian journal …, 1988 - Wiley Online Library
Primary immunization with a single inoculum of either micelles or iscoms containing
influenza A virus glycoproteins failed to induce either B or cytotoxic T (Tc) cell responses. In
contrast, immunization with two inocula of iscoms, but not micelles, resulted in the
appearance of influenza virus‐specific antibody‐secreting cells (ASC) but not Tc cells in the
lung. There was a 10‐fold increase in Tc cell precursor frequency and an increase in ASC
generated by secondary in vitro stimulation of lung cell cultures obtained from mice primed …
influenza A virus glycoproteins failed to induce either B or cytotoxic T (Tc) cell responses. In
contrast, immunization with two inocula of iscoms, but not micelles, resulted in the
appearance of influenza virus‐specific antibody‐secreting cells (ASC) but not Tc cells in the
lung. There was a 10‐fold increase in Tc cell precursor frequency and an increase in ASC
generated by secondary in vitro stimulation of lung cell cultures obtained from mice primed …
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