Changes in peripheral hemodynamics and vasodilating prostaglandins after high-dose short-term ibuprofen in chronically treated hypertensive patients

P Pancera, E Arosio, P Minuz, F Pirante, M Ribul… - … and essential fatty acids, 1996 - Elsevier
The use of cyclooxygenase inhibitors has been seen to reduce the efficacy of many
antihypertensive drugs. However, cyclooxygenase inhibitors are normally non-selective
because they affect both vascular tissue, where the endothelial prostanoids exert principally
a vasodilatory action, and the kidneys, where they also play an important role in regulating
hydroelectrolytic metabolism by redistribution of intraparenchymal flow. To evaluate the
relative importance of vascular district in the hypertensive patient, we administered …
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