Characterization of BIV Env core: implication for mechanism of BIV-mediated cell fusion
Entry of lentiviruses, such as human immunodeficiency virus type 1 (HIV-1) and simian
immunodeficiency virus (SIV), requires folding of two heptad repeat regions (HR1 and HR2)
of gp41 into a trimer-of-hairpins, which subsequently brings virus and cell membrane into
fusion. This motif is a generalized feature of viral fusion proteins and has been exploited in
generating antiviral fusion agents. In the present paper, we report structural characters of
Env protein from another lentivirus, bovine immunodeficiency virus (BIV), which contributes …
immunodeficiency virus (SIV), requires folding of two heptad repeat regions (HR1 and HR2)
of gp41 into a trimer-of-hairpins, which subsequently brings virus and cell membrane into
fusion. This motif is a generalized feature of viral fusion proteins and has been exploited in
generating antiviral fusion agents. In the present paper, we report structural characters of
Env protein from another lentivirus, bovine immunodeficiency virus (BIV), which contributes …
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