Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity
RM Campbell, BD Anderson, NA Brooks… - Molecular cancer …, 2014 - AACR
Abstract p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in
response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α
MAPK phosphorylates a number of substrates, including MAPKAP-K2 (MK2), and regulates
the production of cytokines in the tumor microenvironment, such as TNF-α, interleukin-1β (IL-
1β), IL-6, and CXCL8 (IL-8). p38α MAPK is highly expressed in human cancers and may
play a role in tumor growth, invasion, metastasis, and drug resistance. LY2228820 …
response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α
MAPK phosphorylates a number of substrates, including MAPKAP-K2 (MK2), and regulates
the production of cytokines in the tumor microenvironment, such as TNF-α, interleukin-1β (IL-
1β), IL-6, and CXCL8 (IL-8). p38α MAPK is highly expressed in human cancers and may
play a role in tumor growth, invasion, metastasis, and drug resistance. LY2228820 …
[PDF][PDF] Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with anti-tumor activity
F Stancato, JJ Starling, C Tate, JA Velasco, Y Wang… - academia.edu
Abstract p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in
response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α
MAPK phosphorylates a number of substrates, including MAPKAP-K2 (MK2), and regulates
the production of cytokines in the tumor microenvironment, such as TNFα, IL-1β, IL-6 and
CXCL8 (IL-8). p38α MAPK is highly expressed in human cancers and may play a role in
tumor growth, invasion, metastasis and drug resistance. LY2228820 dimesylate (hereafter …
response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α
MAPK phosphorylates a number of substrates, including MAPKAP-K2 (MK2), and regulates
the production of cytokines in the tumor microenvironment, such as TNFα, IL-1β, IL-6 and
CXCL8 (IL-8). p38α MAPK is highly expressed in human cancers and may play a role in
tumor growth, invasion, metastasis and drug resistance. LY2228820 dimesylate (hereafter …
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