[HTML][HTML] Chemical genetics: elucidating biological systems with small-molecule compounds
M Kawasumi, P Nghiem - Journal of investigative dermatology, 2007 - Elsevier
Chemical genetics employs diverse small-molecule compounds to elucidate biological
processes in a manner analogous to the mutagenesis strategies at the core of classical
genetics. Screening small-molecule libraries for compounds that induce a phenotype of
interest represents the forward chemical genetic approach, whereas the reverse approach
involves small molecules targeting a single protein. Here, we review key differences
between the goals for small-molecule screening in industry versus academia, recent …
processes in a manner analogous to the mutagenesis strategies at the core of classical
genetics. Screening small-molecule libraries for compounds that induce a phenotype of
interest represents the forward chemical genetic approach, whereas the reverse approach
involves small molecules targeting a single protein. Here, we review key differences
between the goals for small-molecule screening in industry versus academia, recent …