Chip‐on‐beads: Flow‐cytometric evaluation of chromatin immunoprecipitation
Abstract Background: Chromatin immunoprecipitation (ChIP) is a widely used technique for
the detection of in vivo DNA–protein interactions underlying epigenetic regulation. The
standard readout of ChIP is based on semi‐quantitative or quantitative PCR measurements;
however, the development of alternative platforms with high throughput potentialities is
expected to facilitate the introduction of this method into routine diagnostics. Methods: We
have established a flow‐cytometry‐based alternative for the evaluation of ChIP data. The …
the detection of in vivo DNA–protein interactions underlying epigenetic regulation. The
standard readout of ChIP is based on semi‐quantitative or quantitative PCR measurements;
however, the development of alternative platforms with high throughput potentialities is
expected to facilitate the introduction of this method into routine diagnostics. Methods: We
have established a flow‐cytometry‐based alternative for the evaluation of ChIP data. The …
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