[HTML][HTML] Chromosome 1q21 translocation and spermatogenesis failure: two case reports and review of the literature

R Li, X Wang, S Feng, X Yang, Q Zhang, P Zhan - Medicine, 2019 - journals.lww.com
Interventions: After genetic counseling and informed consent, 1 patient (Case 2) chose
microsopic testicular sperm extraction (micro-TESE). Outcomes: After micro-TESE, no sperm
was found for the patient. Finally, both patients chose clinical treatment through artificial
insemination with donor sperm. Lessons: These outcomes suggest that breakpoint at 1q21
should be paid attention by physician in genetic counseling, may harbor some genes
associated with spermatogenesis, and deserves further be studied on the function of related …
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