Chronic expression of murine flt3 ligand in mice results in increased circulating white blood cell levels and abnormal cellular infiltrates associated with splenic fibrosis
TSC Juan, IK McNiece, G Van, D Lacey… - Blood, The Journal …, 1997 - ashpublications.org
The effect of chronic expression of flt3 ligand (FL) on in vivo hematopoiesis was studied.
Retroviral vector-mediated gene transfer was used in a mouse model of bone marrow
transplantation to enforce expression of mouse FL cDNA in hematopoietic tissues. As early
as 2 weeks posttransplantation, peripheral blood white blood cell counts in FL-
overexpressing recipients were significantly elevated compared with controls. With the
exception of eosinophils, all nucleated cell lineages studied were similarly affected in these …
Retroviral vector-mediated gene transfer was used in a mouse model of bone marrow
transplantation to enforce expression of mouse FL cDNA in hematopoietic tissues. As early
as 2 weeks posttransplantation, peripheral blood white blood cell counts in FL-
overexpressing recipients were significantly elevated compared with controls. With the
exception of eosinophils, all nucleated cell lineages studied were similarly affected in these …
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