Objective. Endothelial-neutrophil adhesion is crucial for vascular injury, the major cause of
diabetic vascular complications. On the other hand, platelet aggregation inhibitors,
frequently used for diabetic patients with intermittent claudication, have been shown to
decrease the incidence of atherosclerosis-mediated diseases (acute myocardial infarction
and stroke). However, whether these agents act directly on the endothelial reactions to
hyperglycemia remains unclear. Therefore, we examined their direct effects on endothelial …