Clinical relevance of sperm DNA damage in assisted reproduction
N Tarozzi, D Bizzaro, C Flamigni, A Borini - Reproductive BioMedicine …, 2007 - Elsevier
Many studies have shown how a 'paternal effect'can cause repeated assisted reproduction
failures. In particular, with increasing experience of intracytoplasmic sperm injection (ICSI), it
became evident that spermatozoa from some patients repeatedly fail to form viable embryos,
although they can fertilize the oocyte and trigger early preimplantation development. Many
authors have shown how this paternal effect can be traced back to anomalies in sperm
chromatin organization: the spermatozoa of subfertile men are characterized by numerical …
failures. In particular, with increasing experience of intracytoplasmic sperm injection (ICSI), it
became evident that spermatozoa from some patients repeatedly fail to form viable embryos,
although they can fertilize the oocyte and trigger early preimplantation development. Many
authors have shown how this paternal effect can be traced back to anomalies in sperm
chromatin organization: the spermatozoa of subfertile men are characterized by numerical …
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