Comparison of the Aerobic Photoreactivity of A2E with its Precursor Retinal

A Pawlak, M Wrona, M Rózanowska… - Photochemistry and …, 2003 - Wiley Online Library
ABSTRACT A2E (2‐[2, 6‐dimethyl‐8‐(2, 6, 6‐trimethyl‐1‐cyclohexen‐1‐yl)‐1E, 3E, 5E, 7E‐
octatetraenyl]‐1‐(2‐hydroxyethyl)‐4‐[4‐methyl‐6‐(2, 6, 6‐trimethyl‐1‐cyclohexen‐1‐yl)‐1E,
3E, 5E‐hexatrienyl]‐pyridinium) is a blue‐absorbing molecular constituent of human ocular
lipofuscin and contributes to the golden‐yellow emission of this pigment. Lipofuscin
photoproduces toxic reactive oxygen intermediates (ROI), but the specific molecular
components responsible for this phototoxicity remain unidentified. In this article the aerobic …
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