Construction and validation of tissue microarrays of ductal carcinoma in situ and terminal duct lobular units associated with invasive breast carcinoma
XR Yang, LA Charette, M Garcia-Closas… - Diagnostic Molecular …, 2006 - journals.lww.com
Construction of tissue microarrays (TMAs) to efficiently characterize large sets of
noninvasive epithelial lesions in the breast by immunohistochemistry is an appealing
investigative approach, but presents technical challenges. We report methodologic studies
performed to optimize methods for building TMAs from noninvasive breast tissues collected
in a large case-control study of breast cancer. Using a manual arraying technique with 2.0-
mm diameter needles, we constructed TMAs from specimens obtained from 32 women with …
noninvasive epithelial lesions in the breast by immunohistochemistry is an appealing
investigative approach, but presents technical challenges. We report methodologic studies
performed to optimize methods for building TMAs from noninvasive breast tissues collected
in a large case-control study of breast cancer. Using a manual arraying technique with 2.0-
mm diameter needles, we constructed TMAs from specimens obtained from 32 women with …
